Drug intelligence / Profile preview

coenzyme Q10 + feverfew + magnesium

Development stage
Unknown
Lead developer
PiLeJe
Modality
Small Molecules
Administration
Oral
01

Overview

Antemig is a fixed-dose nutraceutical combination containing coenzyme Q10, feverfew (Tanacetum parthenium), and magnesium, developed by PiLeJe for the prophylaxis of migraine in adults. The supplement targets multiple pathophysiological pathways associated with migraines: feverfew contains parthenolide, which inhibits the release of serotonin and pro-inflammatory prostaglandins; coenzyme Q10 acts as an antioxidant and electron carrier to address mitochondrial dysfunction; and magnesium helps correct deficient energy metabolism and neuronal excitability. Clinical evidence suggests that daily supplementation significantly reduces the frequency of migraine attacks, with studies showing a reduction from 4.9 to 1.3 migraine days per month after three months of use.

Brand names
Antemig
Other names
coenzyme Q10 + feverfew + magnesium
02

Targets

COX-3 (Mitochondrially encoded cytochrome c oxidase subunit 3)ND1 (Mitochondrial electron transport chain complex I)

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