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coenzyme Q10 + feverfew + magnesium
- Development stage
- Unknown
- Lead developer
- PiLeJe
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Antemig is a fixed-dose nutraceutical combination containing coenzyme Q10, feverfew (Tanacetum parthenium), and magnesium, developed by PiLeJe for the prophylaxis of migraine in adults. The supplement targets multiple pathophysiological pathways associated with migraines: feverfew contains parthenolide, which inhibits the release of serotonin and pro-inflammatory prostaglandins; coenzyme Q10 acts as an antioxidant and electron carrier to address mitochondrial dysfunction; and magnesium helps correct deficient energy metabolism and neuronal excitability. Clinical evidence suggests that daily supplementation significantly reduces the frequency of migraine attacks, with studies showing a reduction from 4.9 to 1.3 migraine days per month after three months of use.
- Brand names
- Antemig
- Other names
- coenzyme Q10 + feverfew + magnesium
02
Targets
ND1 (Mitochondrial electron transport chain complex I)COX-3 (Mitochondrially encoded cytochrome c oxidase subunit 3)NMDAR (Glutamate receptor ionotropic, NMDA)
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