Drug intelligence / Profile preview

Coffwell-D

Development stage
Unknown
Lead developer
Wellmed Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

Coffwell-D is a combination oral syrup developed and marketed by Wellmed Pharma for the symptomatic relief of cough, nasal congestion, and allergic symptoms associated with the common cold and upper respiratory tract conditions. It is a multi-ingredient formulation containing dextromethorphan hydrobromide, phenylephrine hydrochloride, and chlorpheniramine maleate. Dextromethorphan acts as an antitussive by suppressing the cough reflex in the brain. Phenylephrine is a sympathomimetic decongestant that targets alpha-adrenergic receptors to reduce swelling in the nasal passages. Chlorpheniramine is a first-generation antihistamine that blocks H1 receptors to alleviate sneezing, itching, and watery eyes. This product is positioned as a branded generic in the Indian pharmaceutical market.

Brand names
Coffwell-DCoffwell-D-Wellmed
Other names
Dextromethorphan + Phenylephrine + Chlorpheniramine
02

Targets

SIGMAR1 (Sigma non-opioid intracellular receptor 1)Nicotinic Acetylcholine ReceptorNMDAR (Glutamate receptor ionotropic, NMDA)NET (Norepinephrine Transporter)CaV (Voltage-gated calcium channel protein complex)SERT (Sodium-dependent serotonin transporter)

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