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**Colaren** is a proprietary dietary supplement whose composition and manufacturer were not publicly specified in the available trial record. It was evaluated by the University of Guadalajara as an adjunct to annual 4 mg zoledronic acid for secondary osteoporosis in HIV-positive and HIV-negative men. The registered study compared zoledronic acid plus Colaren with zoledronic acid plus conventional calcium and vitamin D supplementation. No specific pharmacologic target, active ingredient, or mechanism of action for Colaren was disclosed in the public record, and it should not be conflated with zoledronic acid or the comparator calcium and vitamin D supplements.
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