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colchicine
- Development stage
- Approved
- Lead developer
- Takeda
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Colchicine is a plant-derived small molecule alkaloid used primarily to prevent and treat gout attacks, manage familial Mediterranean fever (FMF), and reduce the risk of cardiovascular events in patients with atherosclerosis or multiple cardiovascular risk factors. It is also used for Behçet's disease and pericarditis. The drug works by binding to tubulin and disrupting microtubule polymerization in cells, which impairs the migration of inflammatory cells (such as neutrophils) to sites of inflammation. This action inhibits several inflammatory pathways including the NLRP3 inflammasome assembly and reduces secretion of pro-inflammatory cytokines like interleukin-1β. Colchicine does not affect uric acid production or excretion but modulates innate immunity through its anti-mitotic effects on cell division and cytoskeletal rearrangement[1][3][6][8]. It was originally derived from the autumn crocus (Colchicum autumnale) and has been in medical use since ancient times.
- Brand names
- ColcrysGloperbaLodocoMitigare
- Other names
- Colchicum autumnale alkaloid
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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