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colesevelam + simvastatin
- Development stage
- Phase 4
- Lead developer
- Daiichi Sankyo
- Modality
- Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems
- Administration
- Oral
01
Overview
Colesevelam + simvastatin is a combination therapy used to lower elevated cholesterol levels, particularly low-density lipoprotein cholesterol (LDL-C), in patients with hypercholesterolemia. Colesevelam is a bile acid sequestrant that binds bile acids in the intestine, preventing their reabsorption and promoting increased clearance of LDL-C from the blood. Simvastatin is an HMG-CoA reductase inhibitor (statin) that blocks the rate-limiting step in cholesterol biosynthesis, leading to reduced hepatic cholesterol synthesis and increased uptake of LDL by upregulating hepatic LDL receptors. The combination provides additive reductions in LDL-C compared to either agent alone and is well tolerated. This therapy may be used when monotherapy does not achieve target lipid levels or when additional lowering of LDL-C is desired[1][5][8].
- Other names
- colesevelam hydrochloride
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)
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