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Colflex is a line of oral dietary supplements developed by Mantecorp Farmasa (a division of Hypera Pharma) in Brazil, specifically formulated to support joint and muscle health. The product range includes various formulations such as Colflex Trio, which combines hydrolyzed collagen with undenatured type II collagen, and Colflex Muscular, which includes HMB (beta-hydroxy beta-methylbutyrate) and Vitamin D. The primary mechanism involves providing essential amino acids for cartilage matrix repair and utilizing undenatured type II collagen to induce oral tolerance, thereby reducing the autoimmune-mediated degradation of joint cartilage. These supplements are commonly used as adjuncts in the management of osteoarthritis, joint pain, and age-related muscle loss (sarcopenia).
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