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Colgate Cavity Protection Toothpaste is a commercially available over-the-counter fluoride-based dentifrice developed and manufactured by Colgate-Palmolive. It contains sodium fluoride (or sodium monofluorophosphate) as its active ingredient, which provides anticavity protection by strengthening tooth enamel and remineralizing early decay. In clinical trial contexts, it is frequently utilized as an active comparator or reference control arm to evaluate the efficacy of investigational dental formulations, such as novel toothpastes, in controlling established dental plaque (oral bacterial biofilm) and gingivitis in adults.
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