Drug intelligence / Profile preview

Colgate Fluoride-Free Toothpaste

Development stage
Unknown
Lead developer
Colgate-Palmolive
Modality
Small Molecules
Administration
Topical
01

Overview

Colgate Fluoride-Free Toothpaste refers to a range of oral care formulations developed by Colgate-Palmolive that exclude fluoride, often utilizing alternative agents for cleaning and enamel maintenance. In clinical research, specifically Phase III trials evaluating anti-cavity efficacy, these formulations frequently employ a calcium carbonate (chalk) base, sometimes supplemented with herbal extracts or reactive nano calcium carbonate (RNCC). The mechanism of action involves the mechanical removal of dental plaque through abrasives and the promotion of enamel remineralization by providing a source of calcium to the tooth surface. These products are positioned as alternatives for consumers seeking fluoride-free oral hygiene solutions while still aiming to prevent dental caries through physical cleaning and mineral support.

Brand names
Colgate Herbal (Fluoride-Free)Colgate ZeroColgate Botanicals
Other names
Fluoride free toothpaste in a chalk baseFluoride free toothpaste in a PCC/RNCC baseColgate Fluoride-Free Herbal Toothpaste

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