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Colgate Total Clean Mint is a multi-benefit fluoride toothpaste developed by Colgate-Palmolive. The formulation primarily utilizes stannous fluoride (0.454%) as its active pharmaceutical ingredient, often in combination with zinc phosphate to provide broad-spectrum antimicrobial activity, anti-plaque, and anti-gingivitis benefits. Stannous fluoride works by inhibiting bacterial metabolism and adhesion while promoting the remineralization of tooth enamel to prevent cavities and reduce dentin hypersensitivity. During the COVID-19 pandemic, the product was investigated in clinical trials for its potential to reduce the viral load of SARS-CoV-2 in the oral cavity, aiming to mitigate viral transmission through oral hygiene regimens.
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