colistin + ofloxacin

Colistin + ofloxacin is an antibiotic combination therapy that combines two different classes of antibiotics. Colistin (polymyxin E) is a polymyxin antibiotic that disrupts bacterial cell membranes through a detergent-like mechanism, primarily effective against Gram-negative bacteria including Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii. Ofloxacin is a fluoroquinolone antibiotic that works by inhibiting bacterial DNA gyrase, preventing bacterial DNA replication. This combination may be used to treat multidrug-resistant bacterial infections where single antibiotic therapy is insufficient.