colistin sulfate

Fengweilng is a brand name for colistin sulfate, a polymyxin antibiotic developed and marketed by Shanghai Shyndec Pharmaceutical. It is primarily used for the treatment of severe infections caused by multidrug-resistant (MDR), extensively drug-resistant (XDR), and carbapenem-resistant Gram-negative bacteria, including *Acinetobacter baumannii*, *Pseudomonas aeruginosa*, and *Klebsiella pneumoniae*. The drug acts as a cationic surfactant that binds to the lipid A portion of lipopolysaccharides (LPS) in the outer membrane of Gram-negative bacteria, leading to membrane disruption, increased permeability, and cell death. In China, colistin sulfate is available as a formulation for injection for systemic infections such as pneumonia, bloodstream infections, and complicated urinary tract infections, whereas in many other regions, colistin methanesulfonate is the preferred injectable form.

Brand names

Fengweilng

Other names

Fengweilingcolistin sulfatepolymyxin E sulfate