colla corii asini

Colla corii asini, commonly known as Ejiao or donkey-hide gelatin, is a traditional Chinese medicine (TCM) produced from the skin of the donkey (*Equus asinus* L.) through a meticulous process of decoction and concentration. It is primarily composed of collagen, amino acids, dermatan sulfate, and trace elements. Historically utilized for its hematopoietic and "blood-tonifying" properties, recent clinical research has focused on its efficacy in treating anemia, particularly in pregnant women with thalassemia, and its potential protective effects in chronic obstructive pulmonary disease (COPD). The drug's pharmacological profile involves the modulation of the ER/AKT/NF-κB signaling pathway, where it acts to upregulate estrogen receptors (ERα and ERβ) and inhibit the pro-inflammatory AKT/NF-κB axis, thereby reducing the production of inflammatory mediators like TNF-α and IL-1β while enhancing anti-inflammatory markers such as IL-10.

Brand names

Dong-E Ejiao

Other names

EjiaoE'jiaoDonkey-hide gelatinCCA阿胶