collagen + polyhexamethylenbiguanide hydrochloride

Collagen + polyhexamethylenbiguanide hydrochloride is a **combination wound dressing** consisting of a native Type I collagen matrix combined with the broad-spectrum antimicrobial **polyhexamethylenbiguanide hydrochloride (PHMB)**. The product, often referenced as PCMP (porcine collagen matrix with PHMB), is designed for chronic and acute wound management. Collagen serves as a scaffold promoting granulation tissue formation and supporting wound closure, while PHMB acts as an antimicrobial agent by binding to the negatively charged phospholipids on microbial cell membranes, disrupting their integrity, and causing cell death. PHMB additionally inhibits microbial DNA replication and transcription by binding nucleic acids. This combination is intended as a medical device for wound care, specifically as an effective barrier against microbial colonization and biofilm formation in the dressing, without damaging newly healing tissue. The collagen + PHMB matrix is approved in the United States as a Class II FDA-cleared medical device (510(k) #K051647), and is supplied dry in sterile sheet form for topical application to wounds[1][5][6].

Brand names

PCMP

Other names

porcine collagen matrix with PHMBpurified collagen matrix plus polyhexamethylene biguanidenative type I collagen matrix with polyhexamethylene biguanide hydrochloride