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Collagen II peptide refers to peptides derived from Type II collagen, a major structural component of cartilage. These peptides are often used as dietary supplements to support joint health. One example, undenatured type II collagen, is derived from marine sources like enzymatically processed salmon cartilage and bone. It is being investigated for its potential to reduce activity-related knee discomfort and improve functional performance in healthy adults. It is typically administered as a once-daily oral supplement. Its proposed mechanism involves inducing oral tolerance to collagen, thereby modulating the immune response related to joint health.
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