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collagen scaffold-University of Alabama at Birmingham
- Development stage
- Unknown
- Lead developer
- University of Alabama at Birmingham
- Administration
- Topical
01
Overview
The term **collagen scaffold-University of Alabama at Birmingham** refers to the collagen-based biomaterials evaluated by the University of Alabama at Birmingham (UAB) for regenerative endodontic procedures, specifically for the regeneration of dental pulp tissue in necrotic immature permanent teeth. In clinical research led by UAB (notably trial NCT03318328), two primary scaffolds are investigated: **Syn-Oss**, a novel FDA-approved collagen-hydroxyapatite composite material, and **Colla-Plug**, a traditional absorbable collagen scaffold derived from bovine Achilles tendon. These scaffolds are placed within the disinfected root canal space to provide a three-dimensional structural matrix that supports the attachment, migration, and differentiation of mesenchymal stem cells. This process aims to restore pulpal vitality and promote continued root development (apexogenesis) in teeth that have lost vitality due to infection or trauma.
- Brand names
- Syn-OssColla-Plug
- Other names
- Collagen-hydroxyapatite scaffoldCollagen ScaffoldAbsorbable collagen wound dressing
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