collagen type II peptide 707-721

Collagen type II peptide 707-721, often designated as **p707**, is a synthetic peptide fragment corresponding to amino acid residues 707-721 of mouse type II collagen (CII). It represents an immunodominant epitope of self-CII and has been primarily investigated in preclinical research for the treatment of autoimmune conditions, specifically rheumatoid arthritis, using the collagen-induced arthritis (CIA) murine model. Administered intranasally, the peptide is designed to induce mucosal tolerance, a process that leverages the gut- or nasal-associated lymphoid tissue to suppress systemic immune responses. The primary mechanism of action is **bystander suppression**, where the induction of regulatory T cells (Tregs) specific to the p707 epitope leads to the secretion of anti-inflammatory cytokines (such as TGF-beta or IL-10) that suppress the inflammatory attack against other epitopes of the collagen molecule within the joints. Research indicates that while partially effective, the treatment typically requires high doses and prolonged administration to achieve significant therapeutic outcomes in animal models.

Other names

mouse type II collagen peptide 707-721p707 peptidep-707 peptidep 707 peptidecollagen type II (707-721)