collagenase-2

**Collagenase-2** (also known as collagenase type 2) is a purified protein enzyme preparation isolated from *Clostridium histolyticum*, prepared to contain higher clostripain activity compared to other collagenase types[3][7]. It is mainly used for the isolation of primary cells from tissues such as bone, heart, liver, thyroid, and salivary gland, due to its proteolytic action on collagen and extracellular matrix proteins[3][7]. Its main clinical application is in research and laboratory contexts for tissue dissociation and cell isolation, rather than as a direct pharmaceutical for human therapy. It hydrolyzes collagen by cleaving the collagen triple helix and is distinguished from other collagenases by specific enzyme composition and tissue suitability[2][3][7].

Other names

collagenase type 2