Drug intelligence / Profile preview

CollatampG

Development stage
Unknown
Lead developer
Innocoll
Modality
Small Molecules, Recombinant Proteins and Enzymes
Administration
Topical
01

Overview

CollatampG is a sterile, fully absorbable gentamicin-collagen implant used intraoperatively as a local haemostatic and antibiotic delivery device to reduce surgical site infections in high-risk wounds. It consists of a lyophilized matrix of purified bovine type I collagen impregnated with gentamicin sulfate at approximately 2 mg/cm², providing high local aminoglycoside concentrations for at least 72 hours via diffusion and enzymatic degradation of the collagen matrix while the sponge is resorbed over 1–8 weeks depending on the implantation site.[1][3][6][8] The collagen component promotes haemostasis, stabilizes the wound clot, and supports granulation and epithelialization, while locally released gentamicin acts against gentamicin-susceptible bacteria at the surgical wound in cardiac, vascular, orthopaedic, gastrointestinal, colorectal, and other contaminated or dirty procedures as an adjunct to systemic antibiotic prophylaxis.[1][2][3][4][5][6][8][9][10]

Brand names
CollatampGCollatamp G
Other names
gentamicin-collagen implantgentamicin-collagen spongecollagen-gentamicin implantgentamicin-loaded collagen sponge
02

Targets

Bacterial RibosomePYG (Glycogen phosphorylase)

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