colony stimulating factor 1

Colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a cytokine and hematopoietic growth factor that plays an essential role in the regulation of survival, proliferation, and differentiation of hematopoietic precursor cells, particularly mononuclear phagocytes such as macrophages and monocytes. It binds to the colony stimulating factor 1 receptor (CSF1R) to activate downstream signaling pathways. Recombinant and purified forms of CSF1, including lanimostim, mirimostim, and cilmostim, have been developed for clinical use. Mirimostim (marketed as Leukoprol) is approved in Japan for the treatment of neutropenia and to facilitate hematopoietic recovery after bone marrow transplantation or intensive chemotherapy. Other forms have been investigated for indications such as hypercholesterolemia and infectious diseases.

Brand names

CostilateLeukoprol

Other names

CSF-1CSF1CSF 1M-CSFMCSFcilmostimlanimostimmacrophage colony-stimulating factormacrophage colony-stimulating factor 1mirimostimrecombinant colony-stimulating factor 1recombinant human M-CSFrecombinant human colony stimulating factor 1rhCSF-1rhCSF1rhCSF 1rhM-CSFrM-CSF