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Colostrum enriched with anti-influenza antibodies, also known as anti-influenza hyperimmune bovine colostrum (HBC), is a biologic product derived from the first milk of cows immunized with specific influenza virus antigens. This product contains high concentrations of polyclonal antibodies, primarily bovine IgG1, which target viral surface glycoproteins such as hemagglutinin (HA) and neuraminidase (NA). The mechanism of action involves passive immunization, where the orally or intranasally administered antibodies bind to the virus, neutralizing its ability to infect host cells and preventing viral replication. Developed primarily by companies like Immuron (formerly Anadis), this approach aims to provide immediate, broad-spectrum protection against various influenza subtypes, including seasonal and highly pathogenic avian strains (e.g., H5N1), serving as a complementary strategy to traditional active vaccination.
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