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Combined prandial insulin therapy
- Development stage
- Unknown
- Lead developer
- Fakultní nemocnice Hradec Králové
- Modality
- Recombinant Proteins and Enzymes, Peptides
- Administration
- Subcutaneous
01
Overview
Combined prandial insulin therapy (CPIT) is a therapeutic regimen developed by University Hospital Hradec Kralove for the management of type 1 diabetes mellitus. It involves the simultaneous subcutaneous injection of a rapid-acting insulin analogue (insulin aspart) and a short-acting human insulin (Actrapid) in specific ratios (3:1, 1:1, or 1:3) tailored to the glycemic index of the meal. This approach is designed to mimic the dual-wave or square-wave bolus delivery of an insulin pump, providing a more precise match between insulin action and carbohydrate absorption to improve postprandial glycemic control.
- Other names
- Combined prandial insulin therapyCPITJoint Application of Human Insulin and Rapid Insulin Analogue
02
Targets
INSR (Insulin receptor)
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