Combretastatin A4

Combretastatin A4 is a natural stilbenoid phenol derived from the South African willow bush. It is an inhibitor of microtubule polymerization, acting as an anti-tubulin agent that disrupts tumor vasculature and inhibits angiogenesis. Combretastatin A4 binds to tubulin, leading to cytoskeletal changes in endothelial cells, increased vascular permeability, and disruption of tumor blood flow. This results in rapid ischemic necrosis within tumors, particularly targeting areas resistant to conventional therapies. The compound has been investigated primarily for its antitumor activity as both a direct agent and as the active metabolite of the prodrug fosbretabulin (combretastatin A-4 phosphate). Its main therapeutic area is oncology[1][5][6].

Other names

2'-deoxycombretastatin a1combrestatin a4combretastatin 4combretastatin4combretastatin-4