compound 067

Compound 067 is an experimental chalcone-based small molecule identified as a potent inhibitor of ovarian cancer cell growth, specifically targeting the A2780 cell line. Developed through advanced 3D-QSAR (Quantitative Structure-Activity Relationship) modeling and molecular docking studies, this compound was designed to address the challenge of chemoresistance in late-stage ovarian cancer. Its primary mechanism of action involves the inhibition of Thioredoxin reductase 1 (TrxR1), which leads to the intracellular accumulation of Reactive Oxygen Species (ROS). This induction of oxidative stress subsequently triggers apoptotic pathways, resulting in programmed cell death of malignant cells. Compound 067 serves as a lead scaffold for the development of novel chalcone derivatives with optimized electronic and steric properties for enhanced anti-tumor efficacy.

Other names

chalcone derivative 67