compound 072

Compound 072 is a synthetic chalcone derivative identified through 3D-QSAR (Quantitative Structure-Activity Relationship) modeling as a potent inhibitor of ovarian cancer cell proliferation. Specifically evaluated against the A2780 ovarian cancer cell line, the compound demonstrates significant antiproliferative activity, often outperforming standard chemotherapeutic agents like cisplatin in vitro. Its mechanism of action involves the induction of intracellular reactive oxygen species (ROS) accumulation, which leads to oxidative stress and subsequent apoptosis in malignant cells. As a chalcone-based small molecule, it serves as a lead candidate for overcoming drug resistance in gynecological malignancies, although it remains in the early stages of experimental validation and preclinical research.

Other names

(E)-3-(4-fluorophenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one