Compound 074

Compound 074 is a synthetic chalcone derivative identified as a potent anti-cancer agent through 3D-QSAR (Quantitative Structure-Activity Relationship) modeling and experimental validation. It demonstrates high cytotoxicity against ovarian cancer cells, particularly the A2780 cell line, with an IC50 value in the nanomolar range (approximately 0.07 μM). The compound's mechanism of action involves the inhibition of the Epidermal Growth Factor Receptor (EGFR) and the induction of intracellular Reactive Oxygen Species (ROS) accumulation. This leads to oxidative stress-mediated cell cycle arrest at the G2/M phase and the activation of apoptotic pathways. Compound 074 is utilized as a lead scaffold in medicinal chemistry for the development of novel therapeutics aimed at overcoming drug resistance in gynecological malignancies.

Other names

(E)-3-(4-fluorophenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)prop-2-en-1-one4-fluoro-2'-hydroxy-4',6'-dimethoxychalcone