compound 10b

Compound 10b is a novel hybrid molecule developed by merging the structures of melatonin and ferulic acid. It functions as a potent and selective inhibitor of histone deacetylase 6 (HDAC6), demonstrating an IC50 of 30.7 nM and over 25-fold selectivity against other HDAC subtypes. Beyond its HDAC6 inhibitory activity, compound 10b exhibits significant antioxidant properties, comparable to ferulic acid in DPPH radical scavenging and melatonin in ORAC value, along with Cu2+ chelating ability similar to EDTA. It has shown a lack of neurotoxicity in HT-22 cells, pronounced immunomodulatory effects, and notable efficacy in an Alzheimer's disease mouse model, preventing Aβ25-35-induced spatial working and long-term memory dysfunction at a low dose (0.3 mg/kg), suggesting potential disease-modifying properties for neurodegenerative diseases.

Other names

melatonin-ferulic acid hybrid 10b