compound 10f

The designation compound 10f is a non-specific identifier used across various medicinal chemistry studies to refer to distinct research molecules. One significant iteration, also known as **HH0043**, is a small molecule SOS1 (Son of Sevenless 1) inhibitor characterized by a 1,7-naphthyridine scaffold. HH0043 functions as a guanine nucleotide exchange factor (GEF) inhibitor, blocking the SOS1-mediated conversion of KRAS from its inactive GDP-bound state to its active GTP-bound state, thereby inhibiting downstream oncogenic signaling in KRAS-driven cancers such as lung cancer. Another distinct compound 10f is a pyrazolo[3,4-d]pyrimidine derivative that acts as a potent inhibitor of human dihydrofolate reductase (hDHFR). This version has demonstrated the ability to induce apoptosis and arrest the cell cycle in the G1/S phase in various methotrexate-resistant cancer cell lines, including breast (MCF-7) and cervical (HeLa) cancers. Other research compounds sharing this name include a Smoothened (Smo) antagonist for Hedgehog pathway-related cancers and an indomethacin-based COX-2 inhibitor.

Other names

1,7-naphthyridine SOS1 inhibitorpyrazolo[3,4-d]pyrimidine DHFR inhibitor