compound 12e (a9da87)

Compound 12e is an investigational small molecule xanthine derivative that acts as a potent and selective adenosine A2A receptor antagonist. It was identified as the most potent ligand in a series of 1,3-dipropyl-8-phenyl substituted xanthines, exhibiting a Ki value of 0.036 µM for the A2A receptor subtype. In preclinical studies involving guinea pig models, compound 12e demonstrated significant in vivo bronchospasmolytic activity against histamine-induced asthma. This suggests its potential as a therapeutic agent for asthma and other respiratory disorders characterized by bronchoconstriction. The compound was described in research published by Gumber et al. in 2020.

Other names

monosubstituted 3-aminoalkoxyl 8-phenyl xanthine derivativemonosubstituted3-aminoalkoxyl 8-phenyl xanthine derivativemonosubstituted-3-aminoalkoxyl 8-phenyl xanthine derivative