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Compound 451238 is a small molecule antineoplastic drug under investigation for the treatment of soft tissue sarcoma. It is being developed by Royal Marsden NHS Foundation Trust in collaboration with Merck KGaA. The precise mechanism of action has not been publicly defined, and it is considered a new molecular entity. Clinical development has reached Phase I/II trials, primarily targeting advanced or late-stage soft tissue sarcoma, including as combination therapy with radiotherapy[1][2][4].
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