compound 6q

Compound 6q is an experimental small molecule tubulin inhibitor belonging to a series of 1-phenyl-3-(2-phenylpyridin-3-yl)urea congeners. Designed as a structural analog of the anti-cancer agent E7010 (ER-86526), it demonstrates potent anti-proliferative activity against various human cancer cell lines, including prostate (DU-145), lung (A549), cervical (HeLa), and breast (MDA-MB-231) cancers, with IC50 values ranging from 2.03 to 8.14 µM. Mechanistically, compound 6q binds to the colchicine binding site of β-tubulin, disrupting microtubule dynamics and arresting the cell cycle at the G2/M phase. This disruption triggers apoptosis through both nuclear and mitochondrial pathways and has been shown to inhibit cancer cell migration.

Other names

1-phenyl-3-(2-phenylpyridin-3-yl)urea congener 6q