compound 7d

Compound 7d is a novel small molecule flavanone derivative developed by researchers at Sun Yat-sen University for the potential treatment of schizophrenia. It utilizes a dual mechanism of action, acting as an antagonist of the dopamine D2 receptor and an inhibitor of nitric oxide (NO) over-production. This dual approach is designed to modulate dopaminergic pathways associated with psychotic symptoms while simultaneously providing anti-neuroinflammatory effects by reducing microglial NO production. In preclinical mouse models, oral administration of compound 7d has demonstrated the ability to reverse hyperactivity behaviors induced by MK-801 and decrease climbing behaviors induced by apomorphine, suggesting potent antipsychotic potential.

Other names

(s)-2-(2-chlorophenyl)-2,3-dihydro-7-((4-(2-methoxyphenyl)piperazin-1-yl)propoxy)-4h-chromen-4-one(S)-2-(2-chlorophenyl)-7-(3-(4-(2-methoxyphenyl)piperazin-1-yl)propoxy)chroman-4-one