compound 7h

Compound 7h is an experimental **small-molecule antimalarial** from a chirally defined series of **7-chloro-4-aminoquinoline derivatives** designed to overcome **chloroquine resistance** in *Plasmodium* parasites. Preclinical data described activity against chloroquine-resistant malaria, including complete parasitemia suppression at 100, 50, and 25 mg/kg in mice infected with chloroquine-resistant *Plasmodium yoelii*, with survival through day 28, and 100% survival with a 60% curative effect at 10 mg/kg. Its reported mechanism is consistent with the 4-aminoquinoline class, with **strong hematin binding** that is thought to disrupt parasite heme detoxification. No brand name, developer, manufacturer, or clinical-stage development program was identified from the provided context.

Other names

chirally defined 7-chloro-4-aminoquinoline derivative 7h