Drug intelligence / Profile preview

Compound 9

Development stage
Unknown
Modality
Small Molecules
Administration
Intravenous, Ophthalmic, Oral
01

Overview

Compound 9 is a non-specific designation used in various medicinal chemistry studies to identify the ninth compound in a synthesized series. In the context of opioid research, it refers to a highly potent, non-selective opioid antagonist that targets mu, delta, and kappa opioid receptors. This specific compound has been investigated for its ability to reverse overdoses caused by high-affinity synthetic opioids like carfentanil, which are often resistant to standard doses of naloxone. In other research contexts, Compound 9 has been described as a benzenesulfonamide-based carbonic anhydrase inhibitor for reducing intraocular pressure in glaucoma, as well as various organometallic (gold or platinum-based) and heterocyclic candidates with cytotoxic activity against ovarian and colorectal cancer cell lines.

02

Targets

CA12 (Carbonic anhydrase XII)KOR (Kappa opioid receptor)DOR (Opioid Receptor Delta 1)CA2 (Carbonic Anhydrase 2)MOR (Mu opioid receptor)CA9 (Carbonic anhydrase IX)

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