compound 9d

Compound 9d is a synthetic small molecule anticancer agent belonging to a series of 1,2,3-triazole-incorporated 1,3,4-oxadiazole-triazine derivatives. It is specifically distinguished by the presence of a 4-pyridyl moiety, which contributes to its high potency in inhibiting the growth of various human cancer cell lines. In preclinical in vitro studies, compound 9d demonstrated exceptional cytotoxic activity against prostate cancer (PC3 and DU-145), lung cancer (A549), and breast cancer (MCF-7) cells, with IC50 values ranging from 0.16 to 0.51 μM. These values indicate significantly higher potency compared to the standard reference drug etoposide. The compound's design utilizes a hybrid pharmacophore approach, combining triazole, oxadiazole, and triazine rings, which are structural motifs frequently associated with diverse biological activities, particularly in oncology.

Other names

1,2,3-triazole-incorporated 1,3,4-oxadiazole-triazine derivative 9d