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compound chuanxiong tablets

Development stage: Unknown
Lead developer: Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine
Administration: Oral

Overview

Compound Chuanxiong Tablets (Fufang Chuanxiong Pian) is a Traditional Chinese Medicine (TCM) formulation primarily composed of the botanical extracts *Ligusticum chuanxiong* (Chuanxiong) and *Pueraria lobata* (Gegen). It is indicated for the treatment of cardiovascular and cerebrovascular conditions, specifically stable angina pectoris and coronary heart disease associated with the TCM syndrome of heart blood stasis. The therapeutic mechanism involves promoting blood circulation, resolving blood stasis, and improving myocardial blood supply through the dilation of coronary arteries. Key active components include tetramethylpyrazine (ligustrazine) from *L. chuanxiong*, which acts as a non-selective calcium channel blocker, and puerarin from *P. lobata*, which contributes to vasodilation. The drug is currently undergoing Phase 4 clinical evaluation in China, sponsored by Dongzhimen Hospital of the Beijing University of Chinese Medicine, to further establish its efficacy and safety in outpatient populations.

Brand names: Fufang Chuanxiong Pian
Other names: Compound Chuanxiong TabletFufang Chuanxiong Tablets

Targets

ADRB1 (β1)CaV (Voltage-gated calcium channel protein complex)

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