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Compound Duzhong Jiangu Granules

Development stage: Unknown
Lead developer: The Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine
Administration: Oral

Overview

Compound Duzhong Jiangu Granules (Fufang Duzhong Jiangu Keli) is a Traditional Chinese Medicine (TCM) formulation primarily used for the treatment of knee osteoarthritis (KOA). Developed or studied by The Third Affiliated Hospital of Beijing University of Chinese Medicine, it is typically composed of several herbal ingredients, with *Eucommia ulmoides* (Duzhong) as a key component. The formulation is designed to strengthen bones and tendons, alleviate pain, and improve joint function. It is currently being evaluated in real-world registry studies in China to assess its effectiveness and safety both as a monotherapy and in combination with conventional treatments for KOA.

Other names: Fufang Duzhong Jiangu Keli

Targets

ALOX12 (Arachidonate 12-lipoxygenase, 12S type)RANKL (Receptor activator of nuclear factor kappa-B ligand)Transforming growth factor-beta receptor–Smad2/3 signaling (TGF-beta/Smad2/3 signaling)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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