Compound Eleutherococcus senticosus Granule

Compound Eleutherococcus senticosus Granule is a traditional herbal preparation primarily containing Eleutherococcus senticosus, also known as Siberian ginseng or eleuthero. This woody shrub, native to Northeast Asia, has been utilized in Traditional Chinese, Korean, and Japanese medicine for over two millennia. It is recognized for its adaptogenic properties, which help enhance the body's resistance to stress, improve mental and physical endurance, and stimulate the immune system. The pharmacological effects are attributed to various bioactive compounds, including eleutherosides, lignans, saponins, flavonoids, and polysaccharides. The compound granule is currently undergoing clinical investigation for the treatment of insomnia, particularly in cases associated with 'heart and spleen deficiency syndrome' in Traditional Chinese Medicine. Its mechanism of action involves modulating neurotransmitter levels, such as increasing inhibitory neurotransmitters like serotonin (5-HT) and gamma-aminobutyric acid (GABA), while reducing excitatory ones like dopamine (DA) and norepinephrine (NE), thereby contributing to improved sleep. Additionally, it exhibits anti-inflammatory, immunomodulatory, and neuroprotective activities.

Other names

Ciwujia Tablet