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Compound guizhencao is a traditional Chinese medicine (TCM) herbal formulation that includes the herb *guizhencao*, which refers to species in the genus *Bidens*—most commonly *Bidens bipinnata* or *Bidens pilosa*. The formulation is used in TCM for its anti-inflammatory and antimicrobial properties and has been studied for various indications including hypertension and Sjögren’s syndrome. The active constituents of Bidens species include polyacetylenes (with antimicrobial and anti-inflammatory effects), flavonoids such as luteolin and quercetin (noted for their antioxidant and anti-inflammatory actions), friedelane triterpenes, chalcone glycosides, and essential oils. Mechanistically, these compounds are believed to inhibit pathogenic organisms, reduce inflammation via multiple pathways (including cytokine modulation), provide antioxidant effects, and possibly modulate immune responses. Compound guizhencao granules have been evaluated in clinical trials for grade I hypertension using metabolomics approaches to elucidate their mechanism of action[1][2][3][6].
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