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Compound Kushen Gel
- Development stage
- Phase 3
- Lead developer
- Guiyang Xintian Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Vaginal
01
Overview
Compound Kushen Gel (复方苦参凝胶) is an investigational Class 1.1 traditional Chinese medicine (TCM) innovative drug formulated as a topical vaginal gel. Developed by Guiyang Xintian Pharmaceutical and Shandong University of Traditional Chinese Medicine, the formulation is designed to clear heat, dry dampness, kill parasites, and relieve itching (清热燥湿，杀虫止痒). It is currently in Phase III clinical trials in China for the treatment of adult non-menopausal women with bacterial vaginosis who present with the TCM syndrome of damp-heat downward flow (湿热下注证).
- Other names
- 003 project003项目复方苦参凝胶
02
Targets
CASP3 (Caspase-3)CDK1 (Cyclin-dependent kinase 1)CDK2 (Cyclin-dependent kinase 2)CHRNA3 (nAChR α3 subunit)CHRNA5 (Nicotinic acetylcholine receptor alpha-5 subunit)DRD2 (Dopamine D2 Receptor)HPV16 E6 oncoproteinMMP1 (Matrix metalloproteinase-1)MMP2 (Matrix metalloproteinase-2)MMP9 (Matrix metalloproteinase-9)MYC (MYC proto-oncogene protein)MYD88 (Myeloid differentiation primary response protein MyD88)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)PLG (Plasminogen)PRKCA (Protein kinase C alpha)SCN9A (Sodium channel protein type 9 subunit alpha)TLR9 (Toll-like receptor 9)TP53 (Cellular Tumor Antigen p53 R175H)
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