Drug intelligence / Profile preview

compound monoammonium glycyrrhizinate s for injection

Development stage
Unknown
Lead developer
ShanXi PuDe Pharmaceutical
Modality
Small Molecules
Administration
Intramuscular, Intravenous, Subcutaneous
01

Overview

Compound Monoammonium Glycyrrhizinate S for Injection (also known as Compound Ammonium Glycyrrhizinate S, abbreviated CMGSI) is an approved injectable pharmaceutical product developed by Shanxi PuDe Pharmaceutical. The active ingredients include monoammonium glycyrrhizinate S (a beta-form ammonium salt of glycyrrhizic acid derived from licorice root extract), cysteine hydrochloride, and glycine. It is primarily indicated for liver diseases, specifically abnormal liver function and viral hepatitis (including hepatocyte protection and recovery of liver function), as well as toxic hepatitis, traumatic hepatitis, food poisoning, drug poisoning, and drug allergies. The drug exhibits anti-inflammatory, antioxidant, antiviral, and immunomodulatory properties, primarily mediated through the inhibition of HMGB1, 11β-hydroxysteroid dehydrogenase (11β-HSD), phospholipase A2, and the NF-κB signaling pathway.

Brand names
GanmushuMingshilekangNuohaoYouNidi甘木舒明世乐康诺豪尤尼迪
Other names
Compound Ammonium Glycyrrhetate S for InjectionCompound Ammonium Glycyrrhizinate SCompound Ammonium Glycyrrhizinate S for InjectionCompound Monoammonium Glycyrrhizinate SCompound Monoammonium Glycyrrhizinate S for Injection复方甘草酸单铵S注射剂注射用复方甘草酸单铵S
02

Targets

HMGB1 (High mobility group protein B1)HSD11B1 (11-beta-hydroxysteroid dehydrogenase type 1)HSD11B2 (11β-HSD2)NF-κBPLA2 (Phospholipase A2 group IID)

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