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Compound Salvia Dropping Pills
- Development stage
- Phase 4
- Lead developer
- Tasly Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Sublingual
01
Overview
Compound Salvia Dropping Pills (also known as Fufang Danshen Diwan or Dantonic) is a modernized traditional Chinese medicine (TCM) botanical drug developed by Tasly. It is a three-herb combination formula consisting of active extracts from Danshen (Salvia miltiorrhiza), Sanqi (Panax notoginseng), and synthetic borneol (Bingpian) as an absorption enhancer. The drug is primarily indicated for the prevention and treatment of chronic stable angina pectoris and coronary heart disease. It works through multi-target mechanisms, including improving microcirculation, protecting endothelial function, increasing nitric oxide bioavailability, and exerting antioxidant and anti-inflammatory effects. It has completed Phase III clinical trials in the United States under the code name T89.
- Brand names
- DantonicTriCardin
- Other names
- CDDPCardiotonic PillCardiotonic PillsCompound Danshen Dripping PillsDanshen Dropping PillsFufang Danshen Diwan
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)BCL-2 (BCL-2 family)HIF1A (Hypoxia-inducible factor 1-alpha)KDM4A (Lysine-specific demethylase 4A)KDM4EMET (Mesenchymal-epithelial transition factor receptor)PIM1 (Proviral integration site for moloney murine leukemia virus kinase 1)SYK (Spleen Tyrosine Kinase)VEGFA (Vascular endothelial growth factor A)
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