Drug intelligence / Profile preview

compound salvia miltiorrhiza

Development stage
Phase 4
Lead developer
Tasly Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Sublingual
01

Overview

Compound salvia miltiorrhiza, commonly known as Compound Danshen Dripping Pills (CDDP) or Fufang Danshen Diwan, is a standardized Traditional Chinese Medicine (TCM) formulation. It primarily consists of extracts from *Salvia miltiorrhiza* (Danshen), *Panax notoginseng* (Sanqi), and synthetic or natural Borneol. Developed primarily by Tasly Pharmaceuticals, it is widely used for the treatment and prevention of cardiovascular diseases, including chronic stable angina and coronary heart disease. The drug's mechanism of action involves improving coronary microcirculation, inhibiting platelet aggregation, reducing blood viscosity, and providing anti-inflammatory and antioxidant effects. It is formulated as dropping pills (dripping pills) designed for oral or sublingual administration to facilitate rapid absorption. In the United States, a standardized version known as T89 or Dantonic has undergone Phase 3 clinical trials for the treatment of chronic stable angina, making it one of the first TCM products to reach late-stage clinical development under the FDA's botanical drug pathway.

Brand names
Dantonic
Other names
Compound Danshen Dripping PillsCDDPFufang Danshen DiwanCompound Salvia Miltiorrhiza Dropping PillsCompound Salvia Miltiorrhiza Dripping Pills
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PDIA3 (Membrane-associated rapid response steroid-binding receptor)NOS3 (eNOS)NOS2 (Nitric Oxide Synthase 2)P2Y12 (Purinergic P2Y12 receptor)PDE (Phosphodiesterase family)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)PDGFRB (Platelet-derived growth factor receptor beta)NOS1 (nNOS)

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