Drug intelligence / Profile preview

compound vitamin b12

Development stage
Unknown
Lead developer
Wei Luo
Modality
Small Molecules
Administration
Topical
01

Overview

Compound Vitamin B12 is a multi-ingredient topical solution used primarily for the treatment and prevention of oral mucositis, particularly in patients undergoing chemoradiotherapy for head and neck cancers such as nasopharyngeal carcinoma. The formulation typically consists of cyanocobalamin (Vitamin B12), dexamethasone, and lidocaine. Cyanocobalamin is included to facilitate mucosal tissue repair and epithelial regeneration. Dexamethasone, a potent corticosteroid, serves to reduce local inflammation and edema, while lidocaine provides symptomatic relief through local anesthesia. This combination is often used as a mouthwash or local application to reduce the severity and duration of radiation-induced oral lesions and is frequently evaluated in combination with growth factors like rhGM-CSF.

Other names
Compound Vitamin B12 SolutionCompound Vitamin B12 Rinse
02

Targets

MTR (Methionine synthase)MMUT (Methylmalonyl-coenzyme A mutase)GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)

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