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Compound Xiwujia granule + Guipi granule is a combination of two traditional Chinese medicine (TCM) herbal formulations. It is being clinically investigated for the treatment of chronic fatigue syndrome and may have applications in managing cancer-related side effects like fatigue and cognitive impairment. [8, 13, 14, 15] The combination consists of Xiwujia granule, derived from Acanthopanax senticosus (Siberian Ginseng), known for its adaptogenic properties, and Guipi granule (also known as Gui Pi Tang or Earth Restoring Decoction), a classic TCM formula. Guipi granule is designed to tonify Qi (vital energy) and blood, strengthen the spleen's function (a concept in TCM related to digestion and metabolism), and nourish the heart to calm the mind. [3, 7] Its ingredients typically include herbs such as Ginseng, Astragalus root, Longan fruit, and Atractylodes rhizome. [2, 4] The combined therapeutic effect is believed to stem from synergistically addressing fatigue, improving cognitive function, and enhancing overall well-being by modulating the immune system and providing neuroprotective effects. [11, 17]
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