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compound zhebei granule

Development stage: Unknown
Modality: Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration: Oral

Overview

Compound Zhebei Granule is a traditional Chinese medicine herbal formulation used as an adjunct to chemotherapy in the treatment of refractory acute leukemia. Clinical studies have shown that when combined with standard chemotherapy regimens, Compound Zhebei Granule can significantly improve clinical remission rates and reduce the proportion of leukemia stem cells (CD34(+) CD123(+), CD33(+) CD123(+)) in patients with acute myeloid leukemia. The mechanism appears to involve modulation of leukemic cell surface markers and possibly enhancement of chemosensitivity, though precise molecular targets are not fully elucidated. It is administered orally as a granulated preparation during chemotherapy cycles[1][5][7][9].

Other names: compound zhebei granulesCompound Zhebei Granule

Targets

ABCB1 (P-glycoprotein)

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