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Compound Zhenzhu Tiaozhi
- Development stage
- Unknown
- Lead developer
- The First Affiliated Hospital of Guangdong Pharmaceutical University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Compound Zhenzhu Tiaozhi (FTZ) is a traditional Chinese medicine (TCM) capsule formulation developed by The First Affiliated Hospital of Guangdong Pharmaceutical University. It is a multi-herb preparation composed of eight traditional Chinese medicinal herbs, including Rhizoma coptidis, Fructus Ligustri Lucidi, Herba cirsii japonici, Radix Salvia miltiorrhiza, Radix Notoginseng, Cortex Eucommiae, and Fructus Citri Sarcodactylis. FTZ is primarily investigated for the treatment of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Its mechanism of action involves the modulation of the PI3K-AKT and HIF-1α signaling pathways, regulation of lipid metabolism-related genes, and influence on the gut-liver axis to reduce hepatic steatosis and inflammation. The formulation has been used clinically in China for over a decade to treat hyperlipidemia and metabolic syndrome.
- Brand names
- Fufang-Zhenzhu-TiaozhiFTZFu Fang Zhen Zhu Tiao Zhi
- Other names
- Fufang Zhenzhu TiaozhiFTZ capsuleZhenzhu Tiaozhi capsule
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)
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