Drug intelligence / Profile preview

Comtrex

Development stage
Unknown
Lead developer
Bristol Myers Squibb
Modality
Small Molecules
Administration
Oral
01

Overview

**Comtrex** is a brand name for combination over-the-counter medications formulated to provide symptomatic relief from common cold, flu, allergies, sinusitis, and related respiratory illnesses. Typical formulations include **acetaminophen** (paracetamol) as an analgesic and antipyretic for pain, headache, fever, and sore throat; a decongestant such as **pseudoephedrine** or **phenylephrine** to reduce nasal and sinus congestion; and an antihistamine like **brompheniramine** or **chlorpheniramine** to alleviate runny nose, sneezing, and itching. Some variants add **dextromethorphan** as a cough suppressant. Developed and previously marketed by companies including Novartis Consumer Health and Bristol-Myers, it is available in tablets, caplets, or liquids, primarily indicated for temporary relief of minor aches, cough, congestion, and associated symptoms without treating underlying causes.[1][2][3][4][7][8][9]

Brand names
Comtrex
Other names
Comtrex Cold CoughComtrex Maximum Strength Cold and CoughComtrex Acute Head ColdComtrex Day/Night Severe Cold-Sinus
02

Targets

NMDAR (Glutamate receptor ionotropic, NMDA)CaV (Voltage-gated calcium channel protein complex)HRH1 (Histamine H1 Receptor)

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