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concentrated growth factor
- Development stage
- Phase 3
- Lead developer
- Silfradent
- Modality
- Adoptive Cell Transfer → Cell Therapies
- Administration
- Topical, Intradermal, Subcutaneous, Intraarticular, Intramuscular, Local Implant
01
Overview
Concentrated growth factor (CGF) is an autologous platelet concentrate developed by Sacco in 2006. It is obtained from venous blood through a specific differential continuous centrifugation process without using anticoagulants. CGF contains a fibrin-rich matrix with activated platelets, leukocytes (including CD34+ stem cells), and various growth factors such as TGF-β, VEGF, PDGF, EGF, and others. It serves as both a scaffold for tissue regeneration and a continuous delivery system for growth factors, promoting healing in various applications including facial rejuvenation, wound healing, bone regeneration, and dental/oral surgeries.
- Other names
- CGFCGF-CD34CGF-CD-34CGF-CD 34
02
Targets
PDGFRA (Platelet-derived growth factor receptor alpha)TGFBR (TGF-beta receptor)
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