conestat alfa

Conestat alfa is a recombinant analogue of the human C1 esterase inhibitor (C1-INH), produced using recombinant DNA technology in the milk of transgenic rabbits. It is a soluble, single-chain glycoprotein with an amino acid sequence identical to endogenous human C1-INH. Conestat alfa functions by inhibiting several proteases involved in the contact and complement systems, specifically activated C1s, kallikrein, factor XIIa, and factor XIa. This inhibition helps control excessive vascular permeability and inflammation associated with acute attacks of hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency. The drug increases plasma levels of functional C1-INH activity and restores complement homeostasis in HAE patients[1][2][4][6]. Conestat alfa is approved for use in adults and adolescents aged 13 years or older for the treatment of acute HAE attacks[3].

Brand names

Ruconest

Other names

recombinant human C1 esterase inhibitorrhC1-INHrhC-1-INHrhC 1-INH